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The noticed deficiency of an important accumulation of PHN in Mind adhering to the intraventricular administration of (+)-amphetamine as well as formation of appreciable quantities of PHN from (+)-POH in Mind tissue in vivo supports the look at that the aromatic hydroxylation of amphetamine next its systemic administration occurs predominantly during the periphery, and that POH is then transported from the blood-Mind barrier, taken up by noradrenergic neurones in brain where (+)-POH is converted in the storage vesicles by dopamine β-hydroxylase to PHN. ^
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